A. Immunodeficiencies- Immunodeficiency disorders disrupt immune function, making affected individuals more susceptible to infections. These conditions may be primary (inherited) or secondary (acquired).
Common Symptoms:
Persistent, frequent, or severe infections that are difficult to treat
Infections that are unusually prolonged
Opportunistic infections (those that typically do not affect individuals with a healthy immune system)
Unexplained recurrent fevers
Chronic fatigue or lack of energy
Digestive issues such as chronic diarrhoea, abdominal pain, nausea, or loss of appetite
Persistent swollen lymph nodes
Delayed growth and development in children
Blood disorders, including anaemia or low platelet counts
Inflammation and infections affecting internal organs
Specific Immunodeficiency Example: Common Variable Immunodeficiency (CVID)
CVID is typically diagnosed in adulthood, though symptoms may manifest in childhood. It is characterized by insufficient levels of immunoglobulins IgG, IgA, and IgM.
Common Symptoms:
Recurrent infections, particularly affecting the respiratory tract (e.g., sinusitis, pneumonia, bronchitis,
ear infections) and gastrointestinal system (e.g., abdominal pain, nausea, vomiting, diarrhea).
Other possible manifestations include:
Chronic rhinitis
Swollen lymph nodes
Unexplained weight loss
Joint pain
CVID patients are also at increased risk for autoimmune disorders, certain malignancies, and chronic pulmonary diseases.